Nucleic Acid Vaccines Based on htDNA-chip^®

Nucleic Acid Vaccines Based on htDNA-chip^®

What is the nucleic acid vaccines?

The function of the nucleic acid vaccines is to directly introduce the viral gene fragments (DNA or RNA) encoding a certain antigen protein into animal cells and produce the antigen protein through the protein synthesis system of the host cell. So that the foreign gene can be expressed in the animal cell. Through inducing the host to produce specific humoral and cellular immune responses to the antigen protein, we can achieve the purpose of preventing and treating diseases. Nucleic acid vaccines aim to inject naked nucleic acid codes of specific components of pathogenic microorganisms directly into the body. These vaccines are currently developed around the world including malaria, influenza, rotavirus, HIV and so on. The difference between the two nucleic acid vaccines is that the DNA vaccine is firstly transcribed into mRNA and then protein is synthesized, while the mRNA vaccine is directly synthesized. 

Compared with traditional vaccines, emerging nucleic acid vaccines have the following advantages

• The dangers that still exist in traditional attenuated vaccines have been eliminated;
• After injection, long-term immunity can be produced without increasing the dose;
• The genes of multiple pathogens can be installed on the same plasmid, reducing the number of injections;
• DNA is not easy to inactivate and convenient to store.

Fig.1 The mechanism of DNA vaccines to activate immune response

What can htDNA-chip^® platform do in nucleic acid vaccines?

The nucleic acid vaccines development process is mainly divided into the following steps: isolation and screening of pathogenic genes, sequencing of pathogenic genes, targeted cloning of antigen genes, introduction of recombinant genes into recipient cells, screening and identification of recombinant genes, and large-scale antigen gene synthesis. As we all know, time is extremely precious for vaccines development, and every second of delay means that more people who have not been vaccinated will die. htDNA-chip^® technology platform can greatly shorten the vaccine development time and  also ensure accuracy.

Fig.2 htDNA-chip^® in DNA vaccines development

Advantages of htDNA-chip^® in nucleic acid vaccines

• htDNA-chip^® can greatly facilitate the vaccine development process

The high-throughput htDNA-chip^® technology platform can greatly reduce unnecessary time consumption, and shift the focus of the vaccine development to research. The platform can greatly accelerate the development of vaccines.

• htDNA-chip^® can give flexible and rapid customization of the sequencing library for different antigen genes

The silicon-based htDNA-chip^® technology platform can realize the genome sequencing of specific pathogenic viruses in a short period of time, and establish a complete genome library of pathogenic viruses. Based on this, htDNA-chip^® can quickly develop next-generation sequencing panels for virus detection and sample characterization. Subsequently, the platform minimizes the time required for gene fragment cloning through high-throughput gene cloning. htDNA-chip^® allows multiple antigen genes to be loaded at the same time to allow rapid development of subunit vaccines during the gene cloning process.

• htDNA-chip^® can ensure 100% safety performance of the final nucleic acid vaccine products

htDNA-chip^® can achieve high efficiency and high precision in the mass production of vaccines. The safety of vaccines developed through our technology platform can be absolutely guaranteed.

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