Decoding Based on htDNA-chip^®

Decoding Based on htDNA-chip^®

The overview of the decoding in DNA storage

At this stage, the most commonly used storage tool is the hard disk. Its working principle is to use the polarity of specific magnetic particles to record data. When reading data, the magnetic head converts the different polarities of the magnetic particles into different electrical pulse signals, and then uses the data converter to convert these original signals into data that can be used by the computer. The writing operation is just the opposite. In addition, there is a storage buffer in the hard disk, which is designed to coordinate the difference in data processing speed between the hard disk and the host. The data stored by DNA is read by DNA sequencing to read the base sequence. Digital storage media not only need to have the necessary characteristics such as large storage capacity and long storage time, but also be able to quickly read the data at any time to obtain the required information after the data is stored. The speed of DNA sequencing determines the speed of reading information. First-generation sequencing has high cost and low throughput. Compared with first-generation sequencing, high-throughput next-generation sequencing is more suitable for reading DNA data.

What can htDNA-chip^® platform do in DNA decoding?

Decoding and translating the DNA that stores information is equivalent to the reverse process of encoding. The process of translating DNA is the process of DNA sequencing. Our silicon-based htDNA-chip^® technology platform can simultaneously sequence multiple DNA strands to be decoded. Through the next-generation sequencing, multiple DNAs can be sequenced simultaneously in a single run, and the information carried by the DNA can be read in a high-throughput manner. After the DNA sequence is detected by high-throughput, the detected base sequence is imported into the binary decoder, and the information can be read with high efficiency. In the DNA decoding process, the technology platform uses next-generation sequencing, which greatly accelerates the decoding process of the information stored in the DNA. Although DNA storage has many advantages over traditional storage methods, the relatively slow reading of information has always been a big problem. htDNA-chip^® can greatly shorten the time through high-throughput next-generation sequencing technology, and promote the application of DNA in information storage.

Fig.1 htDNA-chip^® in the process of DNA decoding in DNA storge

• High-throughput next-generation sequencing can greatly save the sequencing time
• High-throughput next-generation sequencing can speed up the sequencing time while ensure that the readout of the sequence is accurate

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